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Dienedione Depot (EVOLIX) 100mg x 10ml/Vial
Dienedione Depot
Anabolic/Androgenic Ratio: 100-200/10-50
Effective Dosage (Men): 200-500mg/week
Effective Dosage (Women): Not Recommended
Duration of Effect: 4-5 days
Detection Period: 4-6 weeks (possibly 3 months+)
The Ultimate Dry Compound: Dienedione Depot!!!
Zero moisture retention. For extreme cuts and a hard look with visible veins.
Dienedione Depot is a prohormone injection that enjoys overwhelming support in the cutting phase, where body fat is reduced to the absolute minimum, and in lean bulking, where no excess fat is added.
As a derivative of 19-nandrolone, this product does not induce aromatase (estrogen feminization) due to its structure, making it the ultimate weapon for elite trainees aiming for a “sculpted, dry physique” without swelling.
Product Profile
• Active Ingredient: Estra-4,9-diene-3,17-dione (Dienedione)
• Properties: While possessing an anabolic effect that intensely builds muscle, it boasts an ideal anabolic/androgenic ratio that minimizes the risk of masculinizing side effects such as hair loss and acne. It is converted in the body into the powerful active metabolite “Dienolone.”
The overwhelming advantages of taking it as “Depot (injectable)”
Why injection is “more efficient and powerful”
When administered orally, while it is converted to dienolone by 17β-HSD in the liver, a large portion is converted into “mere waste (inactive metabolites)” by other detoxification enzymes (such as cytochrome P450) and excreted in urine. This is called the first-pass effect.
However, with injection, this “simultaneous thinning in the liver” can be completely avoided. It is transported directly to the muscles and tissues throughout the body via the bloodstream, and is converted to dienolone precisely by the 17β-HSD present there. Therefore, even in small amounts, it exerts a far more powerful anabolic (muscle-building) effect than oral administration.
Compared to the conventional oral drug TRENADROL, Dienedione Depot has the following three decisive advantages:
1. Complete avoidance of hepatotoxicity (non-methylation)
◦ Oral prohormones are “17α-alkylated (methylated)” to withstand metabolism in the liver, which places a heavy burden on the liver. This drug is non-methylated, completely bypassing the first-pass effect in the digestive system and liver, allowing for a cycle design that minimizes the burden on internal organs.
2. Outstanding Bioavailability
◦ While much of the active ingredient is destroyed by stomach acid and hepatic metabolism in oral administration, Depot (injectable) delivers the ingredient directly to the target, resulting in near 100% effectiveness without waste.
3. Stable Blood Concentration (Depot Effect)
◦ The oil-based Depot formula allows the ingredient to be released slowly and gradually in the body. This eliminates the inconvenience of taking capsules multiple times a day and reduces stress on the body caused by fluctuations in blood concentration.
Recommended Dosage, Frequency, and PCT
• Recommended Dosage: 200mg to 500mg (2ml to 5ml) per week
• Recommended Frequency: Every other day or twice a week (e.g., 100mg to 250mg injected on Monday and Thursday)
• PCT is Essential: Use for more than 8 weeks may suppress your own testosterone secretion (HPTA axis). For safety and maximum effect, always perform PCT (Post-Cycle Therapy) for at least 4 weeks after completing a cycle.
Bulking vs. Cutting: Which is better?
Dienedione Depot is most effective for “cutting (weight loss/competition preparation)” and “lean bulking (pure muscle hypertrophy).”
• Cutting (Recommendation Level: ★★★★★)
◦ Maintains muscle output even under calorie restriction and prevents catabolism (muscle breakdown). Because it is not converted to estrogen, it does not retain any water, creating the ultimate dry look with thin skin.
• Lean Bulking (Recommendation: ★★★★☆)
◦ Ideal for those aiming for “pure muscle fiber size increase” by eliminating water and fat, rather than “fat-heavy weight gain.”
Female Use and Doping Detection Period
• Female Use: Not Recommended
◦ Although it has a low androgenic index, its strong anabolic properties mean that it is not recommended for women due to the high risk of causing “masculinizing symptoms (irreversible)” such as voice deepening, hirsutism, and clitoral hypertrophy.
• Doping Detection Period: Approximately 4 to 6 weeks
◦ Because metabolites remain in the urine, competitive athletes who comply with official regulations such as WADA (World Anti-Doping Agency) must accurately calculate their off-season before competitions.
The Development Story of Dienedione Depot
Dienedione was originally researched and developed in the 1960s and 1970s by French pharmaceutical giant Roussel-Uclaf and others as a highly anabolic pharmaceutical intermediate.
Later, during the golden age of US supplements in the 2000s, it was rediscovered as an innovative compound (formerly known as Trenadrol, etc.) with a structure remarkably similar to trenbolone but without causing water retention, becoming a massive hit.
This product, “Dienedione Depot,” is a masterpiece that evolves that legendary formula using modern sterile laboratory technology, resulting in an even safer and more efficient 100mg/ml high-purity oil formulation.
Detection Period: Guidelines and Risk Basis
• Typical Detection Window: Approximately 4 to 6 weeks
• Risk of Long-Term Detection: Depending on usage, cycle duration, individual metabolic capacity, and body fat percentage, detection may last up to 3 months or more.
Dienedione Depot (injectable) has a significantly longer detection period for the following reasons:
1. Oil Depot (Sustained-Release) Effect
◦ The injected oil remains in the muscle, and its components are released into the bloodstream in very small amounts each day (sustained release). Therefore, even calculating from the last injection date, it takes several weeks for the components to be completely released from the base oil [UK Government ACMD Report on Dienedione].
2. Lipid Solubility and Tissue Accumulation
◦ Dienedione metabolites and the injected oil are highly lipid-soluble, so they temporarily accumulate in body fat and muscle tissue. Even after blood concentrations decrease, small amounts continue to be excreted in the urine from these tissues, making it easier to detect the drug in tests [UK Government ACMD Report on Dienedione].
- Reference: Wikipedia – Dienedione
- Scientific Facts: Dienedione is a prohormone (steroid precursor) belonging to the 19-nortestosterone (nandrolone) family. Structurally, it lacks a methyl group at the 19th carbon position compared to testosterone and features a distinct diene structure with double bonds at the carbon-4 and carbon-9 positions. It was historically marketed worldwide as a bodybuilding dietary supplement. [1]
- Reference: Wikipedia – Dienolone
- Scientific Facts: Upon ingestion, dienedione is converted within the body into its active form, dienolone, via enzymes such as 17β-hydroxysteroid dehydrogenase (17β-HSD). Bioassay data indicates that dienolone exhibits potent anabolic (muscle-building) activity and an exceptionally high binding affinity for the androgen receptor.
- Reference: PubMed (2024) – Endogenous nature of estra-4,9-diene-3,17-dione in entire male horses
- Scientific Facts: Recent studies published in 2024 by researchers such as Ho et al. demonstrated that dienedione—previously assumed to be purely synthetic—can actually occur naturally (endologously) in uncastrated male horses (colts). Consequently, current anti-doping research published via PubMed – Doping control of estra-4,9-diene-3,17-dione in horses focuses on distinguishing administration from natural occurrence by analyzing glucuronide conjugates. Under the World Anti-Doping Agency (WADA) code, this substance remains strictly prohibited at all times as an Anabolic Androgenic Steroid. [1, 2, 3]
- Reference: UK Government ACMD Report – Advice on the steroid Dienedione
- Scientific Facts: Reports by the UK Advisory Council on the Misuse of Drugs (ACMD) and data from the US Anabolic Steroid Control Act note that dienedione carries physical risks comparable to traditional anabolic steroids. Pharmacologically, it is highly resistant to aromatization (the enzymatic conversion into estrogen), meaning it carries a lower risk of estrogenic side effects like gynecomastia. However, due to severe health risks including hepatotoxicity, cardiovascular strain, and suppression of natural testosterone production, it is strictly controlled as a Class C drug in the UK and a Schedule III Controlled Substance in the US. [1]
